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KMID : 0350519940470010643
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Journal of Catholic Medical College
1994 Volume.47 No. 1 p.643 ~ p.650
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Influence of Chemotherapy on Daily Living Performance Status and Quality of Life in Patients with Head and Neck Cancer
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Abstract
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This study has been performed to evaluate the change of the daily living performance status (Karnofsky performance status ; KPS) and the quality of life(QL), and to see whether there is any correlation between these two variables before and
during
chemotherapy of the head and neck cancer patients receiving induction chemotherapy.
This study included thirty patients who admitted to cancer ward of the department of internal Medicine, Kangnam St. Mary's hospital, Catholic University Medical College, to receive chemotherapy consisted of cisplatin and 5-fluorouracil.
Eleven point scale on Karnofsky performance status(KPS) and 10 questions of QL that was developed by investigator were used for this study.
@ES The results were as follows;
@EN 1. While the scores of KPS(P=.0001) and QL(P=.0001) during the chemotherapy(1 cycle of chemotherapy were undertaken during 6 days) were significantly lower than those of before chemotherapy, there were no significant differences between those
of
each day during chemotherapy.
2. Of the items of QL, appetite(P=.0001), nausea(P=.0001), vomiting(P=.0001) and weakness (P=.0001) were decreased during all 6 days of chemotherapy, while sleepness(P=0.475), drowsiness(p=.0093) and mood(p=.0001) showed significant decrease
during
part of 6 chemotherapy days. Pain and anger didn's show any change during chemotherapy.
3. There were significant correlation between KPS and QL(r>.40, P<.001 or P<.05) during 6 chemotherapy days.
4. During chemotherapy, there were no significant difference in KPS and QL among the different age and sex groups, but it is showed that number of chemotherapy cycle makes significant difference in QL(P=.0229, figure 2).
With above results, It is recognized that the KPS and QL of head and neck cancer patients receiving chemotherapy are decreased during chemotherapy and they are not fully recovered to normal level rapidly by finishing chemotherapy. Therefore more
aggressive supportive therapy and nursing care are required to improve the KPS and QL during chemotherapy.
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KEYWORD
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